新侯的研究室 Publications

生物醫學
BioMedical Publications:

· Hsin-Hou Chang, Hu ST, Huang TF, Chen SH, Lee YHW and Szecheng J Lo. (1993) Rhodostomin, an RGD-containing peptide expressed from a synthetic gene in Escherichia coli, facilitates the attachment of human hepatoma cells. Biochem. Biophys. Res. Commun.190,242-249.　

· Hsin-Hou Chang, Wei-Jern Tsai, and Szecheng J Lo. (1997) Glutathione S-transferase-rhodostomin fusion proteins inhibit platelet aggregation and induce platelet shape change. Toxicon 35,195-204.　

· Hsin-Hou Chang, Chang CP, Chang JC, Dung SZ and Szecheng J Lo. (1997) Application of Recombinant Rhodostomin in Studying Cell Adhesion. J. Biomed. Sci.4,235-243.　

· Hsin-Hou Chang and Szecheng J Lo. (1998) Full-spreading platelets induced by the recombinant rhodostomin are via binding to integrins and correlated with FAK phosphorylation. Toxicon 36,1087-1099.

· Hsin-Hou Chang, S-Y Sheu, and Szecheng J Lo. (1999) Expression of foreign antigens on Escherichia coli surface by an outer membrane protein TraT. J. Biomed. Sci.6,64-70.

· Hsin-Hou Chang, Chi-Hung Lin, and Szecheng J Lo. (1999) Recombinant rhodostomin substrates induce transformation and active calcium oscillation in human platelets. Exp. Cell Res.250,387-400.250,387-400.

· Hsin-Hou Chang, Ko-Nien Shih, and Szecheng J Lo. (2000) Receptor-mediated endocytosis as a selection force to enrich bacteria expressing rhodostomin on surface. J. Biomed. Sci.7,42-50.

· Rong-Hwa Shyu, Men-Fang Shaio, Shiao-Shek Tang, Huey-Fen Shyu, Chi-Feng Lee, Meng-Hung Tsai, Hsin-Hsien Huang, Jiunn-Jye Wey, Jan-Ling Huang, and Hsin-Hou Chang. (2000). DNA vaccination with the Fragment C of botulinum neurotoxin type A elicits protective immunity in mice. J. Biomed. Sci.7,50-57.(Corresponding author)　

· Hsin-Hou Chang, and Szecheng J Lo. (2000) Modification with a phosphorylation tag of PKA in the TraT-based display vector of Escherichia coli. J. Biotechnology.10,115-122.　

· Chih-Pei Chang, Jui-Chin Chang, Hsin-Hou Chang, Wei-Jern Tsai, and Szecheng J Lo. (2001) Positional importance of Pro53 adjacent to the Arg49-Gly50-Asp51 sequence of rhodostomin in binding to integrin alphaIIbbeta3. Biochem. J.357,57-64.

· Hsin-Hou Chang, Huey-Fen Shyu, Yo-Ming Wang, Der-Shan Sun, Rong-Hwa Shyu, Shiao-Shek Tang, and Yao-Shine Huang (2002). Facilitation of Cell Adhesion by Immobilized Dengue Viral Nonstructural Protein 1 (NS1): Arginine-Glycine-Aspartic Acid Structural Mimicry within the Dengue Viral NS1 Antigen. J . Infect. Dis.186,743-751.(Corresponding author). 　

· Hsin-Hou Chang, Jyh-Hwa Kau, You-Ming Wang, Der-Shan Sun, Szecheng J. Lo. (2003). Cell-adhesion and morphological changes are not sufficient to support anchorage-dependent cell growth via non-integrin-mediated attachment. Cell Biol. Int. 27,123-133.(Corresponding author)

· Der-Shan Sun and Hsin-Hou Chang (2003). Differential regulation of JNK in caspase-3 dependent apoptosis of MPP⁺ treated primary cortical neurons and untreated control cells. Cell Biol. Int. 27, 769-777. .

· Jyh-Hwa Kau, Der-Shan Sun, Wei-Jern Tsai, Huey-Fen Shyu, Hsin-Hsien Huang, Hung-Chi Lin, and Hsin-Hou Chang* (2005). Anti-platelet activities of anthrax lethal toxin are associated with suppressed p42/44 and p38 mitogen-activated protein kinase pathways in the platelets. J. Infect. Dis. 192, 1465-1474. (Corresponding author) .

· Szecheng J. Lo and Hsin-Hou Chang (2005) Recombinant snake disintegrins used for mammalian integrin study. Toxin Rev. 24,95-111.

· Der-Shan Suna, Szecheng J. Lo, Chi-Hung Lin, Mei-Shiuan Yu, Ching-Yi Huang, Yao-Fong Chen and Hsin-Hou Chang* (2005). Calcium oscillation and phosphatidylinositol 3-kinase positively regulate integrin a_II_bb₃-mediated outside-in signaling. J. Biomed. Sci. 12, 321-333. (Corresponding author)

· Jui-Chin Chang, Hsin-Hou Chang, Chien-Ting Lin and Szecheng J. Lo. (2005). The integrin a₆b₁ modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets. J. Biomed. Sci. 12, 881-898.

· Der-Shan Sun, Szecheng J. Lo, Wei-Jern Tsai, Chi-Hung Lin, Mei-Shiuan Yu, Yao-Fong Chen and Hsin-Hou Chang* (2005). PI3-kinase is essential for ADP-stimulated integrin a_II_bb₃-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin a_II_bb₃-initiated signaling cross-talks. J. Biomed. Sci. 12, 937-948. (Corresponding author)

· Hsin-Hou Chang, Mei-Fang Tsai, Chia-Pei Chung, Po-Kong Chen, Hsin-I Hu, Jyh-Hwa Kau, Hsin-Hsien Huang, Hung-Chi Lin and Der-Shan Sun. (2006). Single-step purification of recombinant anthrax lethal factor from periplasm of Escherichia coli. J Biotechnol 277-285.

· Ming-Show Wong, Wen-Chen Chu, Der-Shan Sun, Hsuan-Shun Huang, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu, Shang-Feng Hsu, Shih-Lien Wang, and Hsin-Hou Chang* (2006). Visible-light-induced bactericidal activity of a nitrogen-doped titanium photocatalyst against human pathogens. Appl Environ Microbiol 72, 6111-6116. (Corresponding author).

· Hsin-Hou Chang* and Szecheng J. Lo (2007). Snake venom disintegrin rhodostomin served as a molecular tool to dissect the integrin function. Toxin Reviews 26, 189-202. (Corresponding author)

· Shu-Rung Chang, Kung-Jiun Wang, Yan-Feng Lu, Lii-Jia Yang, Wei-Jie Chen, Yu-Hsiang Lin, Hsin-Hou Chang, and Shih-Lien Wang (2007). Characterization of early gamma interferon (IFN-gamma) expression during murine listeriosis: identification of NK1.1(+) CD11c(+) cells as the primary IFN-gamma-expressing cells. Infect Immun 75, 1167-1176.

· Der-Shan Sun, Chwan-Chuen King, Hsuan-Shun Huang, Yung-Luen Shih, Chin-Cheng Lee, Wei-Jern Tsai, Cheng-Ching Yu and Hsin-Hou Chang* (2007). Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice. J Thromb Haemost 5, 2291-2299. (Corresponding author)

· Chia-Liang Cheng, Der-Shan Sun, Wen-Chen Chu, Yao-Hsuan Tseng, Han-Chen Ho, Jia-Bin Wang, Pei-Hua Chung, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu and Hsin-Hou Chang* (2009). The effects of the bacterial interaction with visible-light responsive titania photocatalyst on the bactericidal performance. J Biomed Sci 16, 7. (Corresponding author)

· Jyh-Hwa Kau, Der-Shan Sun, Hsin-Hsien Huang, Ming-Show Wong, Hung-Chi Lin, Hsin-Hou Chang* (2009). Role of visible light-activated photocatalyst on the reduction of anthrax spore-induced mortality in mice. PLoS ONE 4, e4167. (Corresponding author)

· Ming-Show Wong, Der-Shan Sun, Hsin-Hou Chang* (2010). Bactericidal Performance of Visible-Light Responsive Titania Photocatalyst with Silver Nanostructures. PLoS ONE 5, e10394 (Corresponding author).

· Hsuan-Shun Huang, Der-Shan Sun, Te-Sheng Lien and Hsin-Hou Chang* (2010). Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice. Blood, 116, 5002-9 (Corresponding author).

· Jyh-Hwa Kau, Der-Shan Sun, Hsuan-Shun Huang, Te-Sheng Lien, Hsin-Hsien Huang, Hung-Chi Lin, Hsin-Hou Chang* (2010). Sublethal Doses of Anthrax Lethal Toxin on the Suppression of Macrophage Phagocytosis PLoS ONE 5, e14289 (Corresponding author).

· Je-Wen Liou, Ming-Hui Gu, Yen-Kai Chen, Wen-Yi Chen, Yi-Cheng Chen, Yao-Hsuan Tseng, Yu-Jiun Hung, Hsin-Hou Chang* (2011). Visible Light Responsive Photocatalyst Induces Progressive and Apical-Terminus Preferential Damages on Escherichia coli Surfaces. PLoS ONE 6, e19982 (Corresponding author).

· Wen-Ku Chang, Der-Shan Sun, Hao Chan, Pai-Tsang Huang, Wen-Shiang Wu, Ching-Hui Lin, Yao-Hsuan Tseng, Yi-Hung Cheng, Chun-Chieh Tseng and Hsin-Hou Chang* (2011). Visible light responsive core-shell structured In₂O₃@CaIn₂O₄ photocatalyst with superior bactericidal property and biocompatibility. Nanomedicine: Nanotechnology, Biology and Medicine, in press (Corresponding author).

生醫研討會摘要
Conference Papers:

· Chang HH, Sheu SY, Lo SJ. (1993) Construction of an E. coli vector to express a foreign protein on the outer membrane. Abstract No. 253. The 8^th joint annual conference of biomedical science. National Taiwan University Taipei, Taiwan, R.O.C.

· Chang HH, Tsai WJ, Lo SJ. (1995) Bacterially expressed GST-rhodostomin is equally functional in inhibition platelet aggregation and facilitation cell attachment on culture plates. The Chinase Society of Microbiology. National Taiwan University Taipei, Taiwan, R.O.C.

· Chang HH, Chang CP, Lo SJ. (1996) Cell adhesion and morophological change on plates coated with the genetically engineered rhodostomin (A disintegrin). Abstract No. 1420. Mol Biol Cell 7:S-244a. 6th international congress on cell biology & 36th american society for cell biology annual meeting. San Francisco, Calfornia, U.S.A.

· Chang HH, Tsai MH, Chen HM, Tang SS. (1998) Using fluorescence-labeled goat immunoglobulin to detect the cell surface Fc receptor expression. The 25^th military medical research annual meeting. National Defense Medical Center, Taipei, Taiwan, R.O.C.

· Chang HH, Lo SJ, Tang SS. (1998) Membrane viral protein mediated cell adhesion can induce the pseudopodia formation but not support the cell growth. The 25^th military medical research annual meeting. National Defense Medical Center, Taipei, Taiwan, R.O.C.

· Way JJ, Chang HH, Lee CF, Tang SS. (1998) Cytotoxicity of antibody-ricin A chain complex to mouse macrophage cells. The 25^th military medical research annual meeting. National Defense Medical Center, Taipei, Taiwan, R.O.C.

· Chang RJ, Yi YH, Chang HH, Lin CH, Lo SJ. (2002) Various morphological changes of human platelets by activation of a_IIbb₃ and a₆b₁ integrins. Abstract No. 1148. Mol Biol Cell 13:S-204a.42nd american society for cell biology annual meeting. San Francisco, Calfornia, U.S.A.

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